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M9630184.TXT
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1996-02-27
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Document 0184
DOCN M9630184
TI Presence of CD4+ and CD8+ T cells and expression of MHC class I and MHC
class II antigen in horses with Borna disease virus-induced
encephalitis.
DT 9603
AU Bilzer T; Planz O; Lipkin WI; Stitz L; Institut fur Neuropathologie,
Heinrich-Heine-Universitat,; Dusseldorf, Germany.
SO Brain Pathol. 1995 Jul;5(3):223-30. Unique Identifier : AIDSLINE
MED/96048152
AB Tissues from 9 horses and 1 donkey suffering from natural Borna disease
were investigated immunomorphologically. Lymphocytic inflammatory
reactions and increased expressions of MHC class I and class II antigen
were found in the brain as well as in the trigeminal and olfactory
system. Perivascular inflammatory infiltrates were dominated by CD4+ T
cells, whereas the majority of CD8+ T cells were disseminated
intraparenchymally. No evidence of inflammation was found in the retina.
Borna disease virus proteins and nucleic acids were present in the
hippocampus, thalamus and medulla oblongata in all 10 animals, in the
cerebral cortex, retina, trigeminal ganglion and nerve in 9, in the
olfactory epithelium in 6 and in roots and proximal parts of large
peripheral nerves in 3. No evidence of infection was found in the
autonomic nervous system, lung, heart, liver, kidney or gut. BDV-
proteins and nucleic acids were even more abundant in the trigeminal
system than in the olfactory system, suggesting that infection may have
occurred via the trigeminal nerve.
DE Animal Borna Disease/IMMUNOLOGY/*VIROLOGY Brain/IMMUNOLOGY
CD4-Positive T-Lymphocytes/*IMMUNOLOGY CD8-Positive
T-Lymphocytes/*IMMUNOLOGY Equidae/*IMMUNOLOGY Histocompatibility
Antigens/*BLOOD Histocompatibility Antigens Class I/BLOOD
Histocompatibility Antigens Class II/BLOOD Horse Diseases/*IMMUNOLOGY
Horses Inflammation/IMMUNOLOGY Support, Non-U.S. Gov't Support, U.S.
Gov't, P.H.S. JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).